三、研究方向

方向一：新兽药与新制剂创制

1)天然候选药物靶标探寻及分子机制研究

2)新兽药开发及靶向、长效制剂创制

方向二：药代动力学与残留研究

1)中兽药的代谢规律及作用机制研究

2)残留安全性研究

方向三：猪场疫病净化与疫苗研究

1)生猪疾病流行病学调查与猪场疫病净化模式研究

2)生猪疾病ELISA诊断试剂盒研发与疫苗研究

方向四：动物健康养殖研究

1)饲料常见霉菌毒素中毒机理与防控

2)动物健康养殖与低胆固醇猪肉研发

四、工程中心研究团队

七、团队部分发表文章

1. Development and in-house validation of a sensitive LC-MS/MS method for simultaneous quantification of gelsemine, koumine and humantenmine in porcine plasma，Yang K  , Long XM , Liu YC  , Chen FH  , Liu XF , Sun ZL*  , Liu ZY，2018，Journal of  Chromatography B。

2. Biotransformation and tissue distribution of protopine and allocryptopine and effects of Plume Poppy Total Alkaloid on liver drug-metabolizing enzymes，Huang YJ, Cheng P, Zhang ZY, Tian SJ, Sun ZL, Zeng JG, Liu ZY^*，2018，Scientific Reports。

3. Construction of an HRP-streptavidin bound antigen and its application in an ELISA for porcine circovirus 2 antibodies，葛猛,李润成,屈泰龙,余兴龙，2017，Amb Express。

4.Determination of Baclofen Residue in Muscle, Liver, Kidney and Fat of Swine by Liquid Chromatography-Tandem Mass, 杨昆, ,孙志良*,刘兆颖*，Food Analytical Methods，2017.

5.Complete mitochondrial genome of the hybrid of Oreochromisniloticus (♀)?×?Oreochromis aureus (♂)，朱鑫,陈韬*,易谭,宾石玉，Mitochondrial DNA，2016.

6.BCL2 promotor methylation and miR-15a/16-1 upregulation is associated with sanguinarine-induced apoptotic death in rat HSC--t6 cells，孙志良，陈小军，2015.

7. Icariin improves eNOS/NO pathway to prohibit the atherogenesis of apolipoprotein E-null mice，肖红波，隋国光，卢向阳，2017，Canadian Journal of Physiology and Pharmacology。

8. Identification of Bacterial Surface Antigens by Screening Peptide Phage Libraries Using Whole Bacteria Cell-Purified Antisera，胡云霏,赵墩,余兴龙*,胡玉立，2017，Frontiers in Microbiology。

9. Anti-obesity effect of a traditional Chinese dietary habit-blending lard with vegetable oil while cooking，严思思,文利新*,邬静,易金娥袁志航,刘水平，2017，Scientific Reports。

10. T-2 toxin regulates steroid hormone secretion of rat ovarian granulose cells through cAMP-PKA pathway，Jing Wu, Di Tu, Li-Yun Yuan , Jin-e Yi, Yanan Tian，2015，Toxicology Letters。

11. Reductive metabolism of the sanguinarine iminium bond by rat liver preparations，Yong Wu, Zhao-Ying Liu, Yan Cao, Xiao-Jun Chen, Jian-GuoZeng,Zhi-Liang Sun*，2013，Pharmacological Reports。

12.Fingerprint analysis of Gelsemiumelegans by HPLC followed by the targeted identification of chemical constituents using HPLC coupled with  quadrupole-time-of-flight mass spectrometry，刘艳纯,林莉,程辟,孙志良,伍勇,刘兆颖*，2017，Fitoterapia。

13.ZhihangYuan,Froilan Bernard Matias,ZhiliangSun.Koumine AttenuatesLipopolysaccaride-Stimulated inflammation in RAW264,7 Macrophages.Coincidentally Associated with Inhibition of NF-kB,ERK and p38 Pathways.International Journal of Molecular Sciences.2016.

14. Xiao-jun CHEN, Xia BAI, Pei MAI, Jie CAI, Zhao-ying LIU, Hui WANG, Hong-bo XIAO, DONG Wei, Shui-lian WANG, Zhi-liang SUN *.  Angiopoietin-Like Protein 3 Expression is Down-Regulated in Experimentally Pregnant Toxemic Goats，Journal of Integrative Agriculture, Volume 11,Issue 7, pages 101-108 , 2012.

15. Wei Dong; Xiaojun Chen; Ke Liu; Haitao Chen; Zhiliang Sun*. Serum antibody conjugates with gentamicin sulfated targeted to the E. coli for the treatment of colibacillosis. Research in Veterinary Science, Volume 91 pages 136-143，2011.

（*为通讯作者）