柳亦松，男，博士，副教授，湖南省青年骨干教师，1515学术骨干人才、江苏省“双创”人才，美国佐治亚医学院访问学者；任中国生化及分子生物学学会植物蛋白质分会常务理事，中南六省中西兽医结合研究会理事会副秘书长。

近几年共主持国家自然科学基金项目、湖南省自然科学基金项目等课题8项，参与国家重点研发计划，国际合作项目，湖南省重点研发计划等近10项。湖南农业大学兽用中药资源与中兽药创制国家地方工程研究中心和中兽药湖南省重点实验室骨干，主要关注基于高分辨质谱技术的蛋白质组学研究，及多组学结合的动物体内外代谢分子机制和生物信息学研究。目前主要研究方向在：1) 植物源饲料添加剂来源植物的多组学联合研究及合成生物学；2)植物源饲料添加剂对于肠道炎症调控的分子机制研究。已发表论文30余篇，其中SCI论文20篇（单篇最高影响因子 Molecular Plant IF=12.1）。

主要研究领域：中兽药植物资源与作用分子机制

联系方式：

手机: 18684669768/13975199768；

Email：liuyisong@hunau.edu.cn 

学术论文及著作

1.            Yisong Liu, Qi Tang, Pi Cheng, Mingfei Zhu, Hui Zhang, Jiazhe Liu, MengtingZuo, Chongyin Huang, Changqiao Wu, Zhiliang Sun, Zhaoying Liu,（2020）Whole-genome sequencing and analysis of the Chinese herbal plant Gelsemiumelegans,Acta Pharmaceutica Sinica B，Volume 10,Pages 374-382

2.            Wei Liu, Hailin Tang, Asmaa M. I. Abuzeid, Lei Tan, Aibing Wang, Xueping Wan, HaojiZhang,Yisong Liu and Guoqing Li (2020). Protein phosphorylation networks in spargana of spirometraerinaceieuropaei revealed by phosphoproteomic analysis. Parasites & Vectors, 13(1).

3.            Bing Zhou, Zhenglei Shen, Yisong Liu, Chengtao Wang, Qingwu W. Shen, （2019）Proteomic analysis reveals that lysine acetylation mediates the effect of antemortem stress on postmortem meat quality development, Food Chemistry, Volume 293,Pages 396-407

4.            Tan L, Yuan X, Liu Y, Cai X, Guo S, Wang A. Non-muscle Myosin II: Role in Microbial Infection and Its Potential as a Therapeutic Target. Front Microbiol. 2019;10:401.

5.             Wei Liu，Ting Wang，Xuesong Liu，Lei Tan，Yi Liu， Yisong Liu，（2019）Molecular identification of Kalicephalus isolated from snakes in Hunan province, subtropical China， Tropical Biomedicine，Vol.36 No.1 pp.289-29

6.             Liu, X., Liu, Y., Huang, P., Ma, Y., Qing, Z., Tang, Q., Cao, H., Cheng, P., Zheng, Y., Yuan, Z., Zhou, Y., Liu, J., Tang, Z., Zhuo, Y., Zhang, Y., Yu, L., Huang, J., Yang, P., Peng, Q., Zhang, J., Jiang, W., Zhang, Z., Lin, K., Ro, D. K., Chen, X., Xiong, X., Shang, Y., Huang, S., & Zeng, J. (2017). The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism. Molecular Plant, 10(7), 975-989. (Co-First author)

7.            Qing, Z. X., Yang, P., Tang, Q., Cheng, P., Liu, X. B., Zheng, Y. J., Liu, Y. S., & Zeng, J. G. (2017). Isoquinoline Alkaloids and Their Antiviral, Antibacterial, and Antifungal Activities and Structure-activity Relationship. Current Organic Chemistry, 21(18).（Co-corresponding author）

8.            Zeng, J., Liu, Y., Liu, W., Liu, X., Liu, F., Huang, P., Zhu, P., Chen, J., Shi, M., Guo, F., Cheng, P., Zeng, J., Liao, Y., Gong, J., Zhang, H. M., Wang, D., Guo, A. Y., &Xiong, X. (2013). Integration of transcriptome, proteome and metabolism data reveals the alkaloids  biosynthesis in Macleaya cordata and Macleaya microcarpa. PLoS One, 8(1), e53409.（Co-First author）

9.             Liu, Y., Teng, X., Yang, X., Song, Q., Lu, R., Xiong, J., Liu, B., Zeng, N., Zeng, Y., Long, J., Cao, R., Lin, Y., He, Q., Chen, P., Lu, M., & Liang, S. (2010). Shotgun proteomics and network analysis between plasma membrane and extracellular matrix proteins from rat olfactory ensheathing cells. Cell Transplantation, 19(2), 133-146. （First author）

10.        Zuo, Z., Zheng, Y., Liang, Z., Liu, Y., Tang, Q., Liu, X., Zhao, Z., & Zeng, J. (2017). Tissue-specific metabolite profiling of benzylisoquinoline alkaloids in the root  of Macleaya cordata by combining laser microdissection with ultra-high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom, 31(5), 397-410.

11.        Huang, Y. J., Xiao, S., Sun, Z. L., Zeng, J. G., Liu, Y. S., & Liu, Z. Y. (2016). Identification of allocryptopine and protopine metabolites in rat liver S9 by high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. Rapid Commun Mass Spectrom, 30(13), 1549-1559.

12.        Tian, X., Li, S., Liu, Y., & Liu, X. (2016). Transcriptomic Profiling Reveals Metabolic and Regulatory Pathways in the Desiccation Tolerance of Mungbean (Vigna radiata [L.] R. Wilczek). Frontiers in Plant Science, 7, 1921.

13.        Cheng, P., Song, W., Gong, X., Liu, Y. S., Xie, W. G., Huang, L. H., & Hong, Y. H. (2015). Proteomic approaches of Trichoderma hamatum to control Ralstonia solanacearum causing pepper bacterial wilt. International Journal of Agriculture & Biology, 17(6).

14.        Qing, Z. X., Liu, X. B., Wu, H. M., Cheng, P., Liu, Y. S., & Zeng, J. G. (2015). An improved separation method for classification of Macleaya cordata from different geographical origins. Analytical Methods, 7(5), 1866-1871.

15.         Qing, Z. X., Cheng, P., Liu, X. B., Liu, Y. S., Zeng, J. G., & Wang, W. (2014). Structural speculation and identification of alkaloids in Macleaya cordata fruits by high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry combined with a screening procedure. Rapid Commun Mass Spectrom, 28(9), 1033-1044.

16.        Li, Q., Huang, J., Liu, S., Li, J., Yang, X., Liu, Y., & Liu, Z. (2011). Proteomic analysis of young leaves at three developmental stages in an albino tea cultivar. Proteome Science, 9, 44.

17.        Cao, R., Liu, Y., Chen, P., Lv, R., Song, Q., Sheng, T., He, Q., Wang, Y., Wang, X., & Liang, S. (2010). Improvement of hydrophobic integral membrane protein identification by mild performic acid oxidation-assisted digestion. Analytical Biochemistry, 407(2), 196-204.

18.        Huang, P.;  Zhang, Y.;  Xiao, K.;  Jiang, F.;  Wang, H.;  Tang, D.;  Liu, D.;  Liu, Y.;  He, X.;  Liu, H.;  Liu, X.;  Qing, Z.;  Liu, C.;  Huang, J.;  Ren, Y.;  Yun, L.;  Yin, L.;  Lin, Q.;  Zeng, C.;  Su, X.;  Yuan, J.;  Lin, L.;  Hu, N.;  Cao, H.;  Huang, S.;  Guo, Y.;  Fan, W.; Zeng, J., The chicken gut metagenome and the modulatory effects of plant-derived benzylisoquinoline alkaloids. Microbiome. 2018, 6 (1), 211.

在研项目及科研成果

1. 湖南省自然科学基金面上项目，2018JJ2172，血根碱对结肠炎大鼠模型的治疗作用机制研究，2018/01-2020/12，在研，主持。

2. 湖南省教育厅一般项目，17C0765，植物源血根碱对鸡肠道菌群的影响及其机理，2018/01-2020/12，在研，主持。

3. 国家重点研发计划，2017YFD0501500，中兽医药现代化与绿色养殖技术研究，2017/1–2020/12，在研，参与。

4. 国家自然科学基金青年项目，31200615，博落回中苄基异喹啉类生物碱代谢累积相关蛋白质研究，2013/01-2015/12，主持

5. 湖南省自然科学基金青年项目，12JJ4027，基于多级质谱技术研究博落回中别隐品碱代谢调控相关的细胞表面糖蛋白，2012/01-2014/12，主持。

6. 柳亦松，伍勇，唐其，刘兆颖，程辟，中药自动清洗干燥系统，2019.12.12，中国，ZL201922230810

7. 柳亦松，伍勇，唐其，刘兆颖，程辟，中药碾压粉碎装置，2019.12.12，中国，ZL201922229144.5

8. 柳亦松，刘伟，刘兆颖，张扬，程辟，唐其，曼氏迭宫绦虫磷酸化蛋白质组注释系统V1.0，2018.11.9.中国，2018SR898831

9. 柳亦松，程辟，刘兆颖，唐其，陈淼芬，孙运，鸡肠道宏蛋白质组注释系统V1.0，2018.7.21.中国，2018SR591659

10. 柳亦松（9/11），国家二类新兽药博落回提取物与博落回散创制与应用，湖南省科技厅，湖南省科学技术进步奖，一等奖，2015（曾建国，沈建忠，蔡鹏，程辟，吴聪明，罗炼辉，欧阳勇，杜宇，柳亦松，黄复深，张明军）